Dichloroacetic Acid and Cancer


Dichloroacetic acid or DCA is sometimes known as bichloroacetic acid or BCA. It is an analog of acetic acid. It is currently being studied as a treatment for cancer.

One research article (1) looked at DCA and reviewed its cancer-fighting properties. It noted that DCA is an orphan drug that has long been used as an investigational medication for various congenital and acquired disorders of mitochondrial intermediary metabolism. It’s anti-cancer effects were attributed to its ability to reactivate the pyruvate dehydrogenase complex and block mitochondrial pyruvate dehydrogenase kinases.

It blocked the growth of cancer cells and caused programmed cell death, also known as apoptosis. The studies were done on animals with cancer. More clinical studies need to be done to see if DCA could fight cancer in humans with cancer. Source: 1.Kankotia S, et al. Dichloroacetate and cancer:

Source: 1.Kankotia S, et al. Dichloroacetate and cancer: new home for an orphan drug? Biochim Biophys Acta. 2014 Dec;1846(2):617-29.

Dr. Adem Gunes
Dr. Abdullah El-Hossami

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