2-Deoxy-Glucose in the Treatment of Cancer

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Cancer cells metabolize glucose differently than healthy cells. It is also called the “Warburg Effect.”  When the cancer cells use glucose as part of metabolism, anaerobic glycolysis happens to a greater degree when compared to healthy cells.

One study (1) looked into the interference of the Warburg Effect as a way of treating cancer.  It is believed that, by interfering with this process, that cancer cells will be unable to grow. It is because they will not be able to use 2-deoxy-glucose as part of their metabolism.

They found that using 2-deoxy-D-Glucose alone did not affect cancer cells but that it may be useful one day when combined with chemotherapy agents or radiation therapy. More research needs to be done to see if this type of therapy could be helpful to cancer patients.

Source:

  1. Zhang D, et al. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett. 2014 Dec 28;355(2):176-83.

    Dr. Adem Gunes

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