Glutamine may alleviate radiation-induced oral mucositis


Glutamine is the most abundant amino acid in the body. It is called a conditionally essential amino acid since it is essential under certain circumstances like cancer, in which its production is insufficient. This amino acid demands increase, so its supplementation is important to maintain a proper nutritional state.

Radiation therapy can cause mucositis (inflammation of the lining of the mouth), which is characterized by pain, mouth ulcers, infection and bleeding. In this study, glutamine treatment showed a significant benefit with respect to reducing the risk and severity of oral mucositis induced by radiotherapy compared to either placebo or no treatment.

Overall, glutamine significantly reduces the risk and severity of oral mucositis during radiotherapy or chemotherapy.

Source: Leung, Chan. Nutr Cancer. 2016 Apr 4:1-9. [Epub ahead of print]


Dr. Adem Gunes