Probiotics Can Help in Reducing the Undesired Effects of Radiotherapy

The intake of a nutritional supplement based on probiotics can reduce the development of radiation-induced diarrhea

This research aimed to investigate the tolerance and safety of Dixentil, a dietary supplement that relies on zinc and prebiotics. Prebiotics are compounds that promote the development of beneficial bacteria in the gut). Moreover, Dixentil also contains probiotics or healthy bacteria (Lactobacillus acidophilus and L. casei) as well as vitamins of the B group (B1, B2. B6, and nicotinamide) given as a prophylactic therapy to individuals that are receiving pelvic radiotherapy for its efficacy in the prevention and reduction of radiation-related gastrointestinal disorders.

Forty consecutive subjects who were also taking pelvic radiation received Dixentil before starting and during radiotherapy.

Radiation-induced enteritis affected seventeen such subjects. Grade I and grade II diarrhea was observed in fourteen and three patients respectively; no grade III or IV diarrhea was seen.

As a conclusion, use of Dixentil is an easy, safe, and feasible approach to protecting patients against the risk of radiation-induced diarrhea.


Scartoni D, Desideri I, Giacomelli I, Di Cataldo V, Di Brina L, Mancuso A, Furfaro I, Bonomo P, Simontacchi G, Livi L. Anticancer Res. 2015 Oct;35(10):5687-92.

Dr. Adem Gunes