Probiotics reduce radiation-induced diarrhea at the end of the treatment of patients with pelvic cancer
Radical radiation therapy is commonly used for the treating pelvic cancers. In up to 80% of patients who are undergoing radiotherapy will develop a condition termed as ‘acute radiation-induced diarrhea’. The primary purpose of this study-based research was to examine the impact of the probiotic Bifilact(®) on moderate and severe cases of treatment-induced diarrhea during pelvic radiation.
229 patients were analyzed. A group received a standard dose of probiotics (1.3 billion CFU twice a day), another group received a high dose of probiotics (10 billion CFU three times a day) and a group received placebo.
As a conclusion, standard dose of probiotics may reduce radiation-induced grade 2-3-4 diarrhea at the end of the therapy being provided to the patients with pelvic cancer. In patients operated on before radical radiation therapy, a standard dose of probiotics may reduce radiation-induced grade 4 diarrhea. Dietary modifications by a registered dietician seemed to reduce global digestive symptoms.
Demers M, Dagnault A, Desjardins J. Clin Nutr. 2014 Oct;33(5):761-7. doi: 10.1016/j.clnu.2013.10.015. Epub 2013 Oct 24.
Dr. Adem Gunes