Safety of Carboplatin and Paclitaxel in Cancer Patients


Carboplatin is a type of chemotherapy drug used in the treatment of various types of cancer. It is considered to be an effective treatment for ovarian cancer. Researchers wanted to find out if giving carboplatin with paclitaxel was safer than giving other chemotherapy drugs. A total of 73 female participants with advanced ovarian cancer were studied. Some received carboplatin and paclitaxel, after failing to get better after taking cisplatin and cyclophosphamide. It was believed that patients on carboplatin and paclitaxel would have fewer side effects. In the end, about 42 percent of patients had improvement in their cancer after receiving carboplatin and paclitaxel. Some patients developed low WBC counts after the chemotherapy was given. Hair loss and fever were other side effects. Only one patient died of their cancer during treatment. Researchers felt this could be a good therapy for cancer patients who fail on other types of chemotherapy.

Source: 1. Gaustalla JP, et al. Efficacy and safety of the paclitaxel and carboplatin combination in patients with previously treated advanced ovarian carcinoma. Ann Oncol (1998) 9 (1): 37-43.


Dr. Adem Gunes