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Adrenocortical Carcinoma

Adrenocortical Carcinoma

Overview

Adrenocortical carcinoma ko kansar adrenal wani nau'in ciwon daji ne da ba a taɓa samu ba wanda ke tasowa a cikin ɗayan biyun glandon adrenal. Glandar adrenal tana da alhakin samar da kwayoyin halittar ga dukkan sassan jiki. Adrenocortical carcinoma mafi yawanci yana shafar yara ƙanana ko manya a cikin tsakiyar tsakiyar su ko tsakiyar karni na hamsin. Magrenocortical carcinoma yana warkewa idan an gano shi da wuri.

Adrenal gland shine yake

Adrenal gland shine kashi wanda aka haɗu da shi wanda yake saman kowane ɗayan mu. Yana samar da kwayoyin halittu daban-daban, kamar su adrenaline, cortisol, da aldosterone. Kowane ƙwayar cuta ta adrenal yana da cortex da medulla, suna da alhakin samar da nau'ikan kwayoyin halittu daban-daban. Wasu daga cikinsu sune tushen samar da kwayoyin halittar maza da mata. Saboda haka, cutar sankarar mahaifa na iya kasancewa tare da hoto na asibiti iri-iri, ya danganta da nau'in hodar da ake samarwa fiye da kima. Wasu lokuta, alamomin da alamun cutar sankarar mahaifa na iya hadewa da sauran yanayin glandar adrenal ko jikin ɗan adam gaba ɗaya.

Yaya yawancin adrenocortical carcinoma?

Adrenocortical carcinoma yana da wuya, kuma yana shafar kewaye 200 mutane a kowace shekara a Amurka. Yawan rayuwa na shekaru biyar ya dogara da matakin tumo tumo. Idan cutar sankarar daji ce, asarar rayuwan shekaru biyar kusan 74%. Dukkan matakan-SEER-haɗe-haɗe tsawon rayuwa shekaru biyar ne 51%. Karincin adrenocortical yankuna suna da adadin rayuwa na shekaru biyar na 56%, kuma ga waɗanda suke nesa, suna saukad da zuwa 37%.

Menene tsinkayen cututtukan mahaifa?

Abubuwan da ke haifar da cututtukan carcinoma sun dogara da matakin sa. Gabaɗaya, cutar sankarar mahaifa ya bazu cikin hanzari zuwa hanyoyin jini kusa da sauran jikin. Lokacin da ƙwayar ƙwayar cuta tayi aiki, ana iya gano cutar a farkon saboda alamu da alamu. Koyaya, ƙwayoyin da ba su da aikin yi ba za a gane su ba har sai sun watsu zuwa wasu ƙwayoyin. Mastastasis mai nisa na maganin cutar adrenocortical yana nufin mummunan ci gaba. Koyaya, sankarar kansa yana da magani idan an gano shi da wuri.

Menene dalilin ciwon adrenocortical carcinoma?

Masana kimiyya ba su da tabbacin abin da ke haifar da cututtukan mahaifa. Sun yi imani da cewa wasu maye gurbi ko canje-canje a cikin DNA na wasu sel na iya zama alhakin canji na kansa. Adrenocortical carcinoma na iya gudana a cikin dangi gabaɗaya. Abubuwan da mutane tare da tarihin dangi game da cutar sankarar mahaifa yakamata suyi gwaje-gwaje na yau da kullun don gano farkon yiwuwar cutar kansa. Wasu halaye na kwayoyin halitta na iya haɓaka damar haɓaka damar haɓakar cututtukan cututtukan cututtukan cututtukan cututtukan daji. Wadannan akwai wasu daga cikinsu:

  • Beckwith-Wiedemann syndrome
  • Familial adenomatous polyposis (FAP)
  • Maganin cutar kansa mai ƙwayar cuta (HNPC)
  • Cutar Li-Fraumeni
  • Da yawa endocrine neoplasias (MEN1)

Abubuwan haɗari don maganin cutar adrenocortical

As abubuwan haɗari don maganin ciwon daji na adrenocortical, likitoci sun ba da shawarar cewa wasu abubuwan kwayoyin halitta suna kara haɗarin ku don cutar kansa. Wadannan sune wasu daga cikin ingantattun abubuwa:

  • Cutar Li-Fraumeni
  • Beckwith-Wiedemann syndrome
  • Cutar Von Hippel-Lindau
  • Da yawa endocrine neoplasias (nau'ikan 1 da 2)
  • Familial adenomatous polyposis (FAP)
  • Lynch syndrome (ciwon daji na nononlylys na ƙwantar kansa)
  • Carney hadaddun

Yawancin mutane da ke da ɗayan waɗannan ƙwayoyin ƙwayoyin halitta ba sa haɓaka kansa, amma galibi suna kasancewa tare da cutar sankarar mahaifa.

Bayyanar cututtuka da alamun cututtukan adrenocortical carcinoma

Adrenocortical carcinoma na iya gabatar da wasu alamu da alamu masu zuwa:

  • Riba ko riba
  • Jin motsin jikinku ya yi rauni
  • Sabon sabbin launuka ruwan hoda ko shunayya mai ruwan fata
  • Wuce gashin fuska a cikin mata
  • Rashin gashi a kai a cikin mata
  • Ƙananan lokaci
  • Girman ƙirji a cikin maza
  • Murmushi mai ƙyalli
  • Nuna da zubar
  • Atingwan ciki da gas
  • Binciken baya
  • Fever
  • Rashin ci

Wasu ciwan ciki shine yake aiki, ma'ana suna haifar da wuce gona da iri na kwayar halitta. Misali, yawan aldosterone mai yawa na iya haifar da hauhawar jini, yawan kumburi, da rauni a jiki. Yawan fitar da abinci na cortisol na iya haifar da karuwar nauyi, hauhawar jini, rauni mai sauki, hawan jini, ruwan hoda ko alamomin budewa mai launin fata, karin mai a bayan wuya, da zagaye da jan fuska. Matsanancin matakan estrogen a cikin maza na iya haifar da ci gaban nono da raguwa. Mata na iya fuskantar yanayi na lokaci-lokaci ko zubar jinni na farji. A ƙarshe, yawancin testosterone na iya haifar da asarar gashi a kai ko gashin fuska a cikin mata, tare da murya mai zurfi. Maza bazai iya samun canje-canje ba.

Nau'in cututtukan fata adrenal

Ciwon mara na cikin Adrenal na iya zama mai wahala ko kuma rashin aminci. Wadannan suna daga cikin manyan nau'ikan cututtukan dake haifarda cutar sikari:

  • Adenomas
  • Adrenocortical carcinomas
  • Neuroblastomas
  • Cutar

Cutar cutar sankarar carcinoma ta adrenocortical

Don bincika cututtukan adrenal carcinoma, likitan ku zai ɗauki tarihin ku kuma kuyi gwajin jiki. Gwajin da zaiyi da kai zasu taimaka maka wajen kawar da wasu dalilai da kuma tabbatar da bambance bambance. Don bincika matakan hormone kuma ganin idan akwai wasu abubuwan maye, lallai ne a yi gwajin jini da gwajin fitsari. Likitanka na iya bayar da shawarar wasu gwaje-gwaje na hoto, kamar CT, positron emmo tomography (PET), ko scan MRI, don ganin ko akwai wani metastasis, kuma don tsara ciwan. Nazarin dakin gwaje-gwaje game da glandar adrenal na iya zama dole idan likitan ku na zargin cewa kuna da cututtukan mahaifa. Don yin wannan, cire ƙurar haihuwar ka na da matukar muhimmanci.

Menene jiyya don maganin ciwon adrenocortical?

Yin tiyata shine mafi kyawun zaɓi na magani don maganin cutar adrenocortical. Sauran hanyoyin kwantar da hankali ma suna da amfani don hana sake dawowar ciwan. Wasu marasa lafiya na iya samun contraindications game da aiki kuma suna iya buƙatar madadin magani. Koyaya, tiyata ita ce hanya daya tilo da zata iya magance cutar adrenocortical carcinoma. Sauran hanyoyin warkewa waɗanda zasu iya zama dole sune masu zuwa:

  • Magungunan magani tare da Mitotane don rage haɗarin sake dawowa bayan tiyata
  • Radiation far don kashe duk sauran ƙwayoyin cutar kansa
  • Chemotherapy, ta baki ko a cikin ƙwayar cuta, don ya kashe duk wani ƙwayoyin cutar kansa da ke jikinsa

References
https://www.mayoclinic.org/diseases-conditions/adrenal-cancer/diagnosis-treatment/drc-20446405
https://www.webmd.com/cancer/adrenal-carcinoma#3
https://moffitt.org/cancers/adrenal-cancer/diagnosis/risk-factors/
https://www.cancer.org/cancer/adrenal-cancer/about/key-statistics.html

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