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Ifosfamide Fact Sheet – Everything You Should Know

In this Ifosfamide fact sheet, you’ll get to know about the precautions, usage, possible side effects, and the types of cancer that you can treat with this chemo drug.

Ifosfamide Fact Sheet

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Here’s the Ifosfamide fact sheet to get detailed information about Ifosfamide

It Is Used To Treat These Cancers
(Cancer types that you can treat with this chemo drug)

  • Bladder
  • Ovarian
  • Testicular
  • Head and neck
  • Esophageal
  • Lung
  • Breast
  • Cervical
  • Stomach
  • Prostate
  • Lymphomas
  • Neuroblastoma
  • Sarcomas
  • Multiple myeloma
  • Melanoma

How To Take it
(What are the forms of application)

  • Intravenous

Precautions
(Things that you should avoid)

  • Grapefruit
  • Grapefruit juice
  • Verapamil
  • Ketoconazole
  • Rifampin
  • Phenytoin
  • St. John’s wort
  • Fluconazole

Mechanism of Action of Ifosfamide
(How does the drug affect cancer cells)

It sticks to the cancer cell’s DNA (the cell’s genetic code) so that it can’t come apart again, which results in cell death.

Drug Interactions
(Medicine that can affect the chemo drug negatively)

  • Lorazepam
  • Dexamethasone
  • Furosemide
  • Levothyroxine
  • Metoclopramide
  • Vitamin D
  • Fish oil
  • Co-trimoxazole

Reproductive Concerns
(Things that are related to your sexual health)

  • Sperm production may stop
  • You may face vaginal dryness
  • Prevent becoming pregnant
  • Stop breastfeeding

Ifosfamide Side Effects
(Unpleasant effects of the treatment)

  • Nausea
  • Vomiting
  • Hearing loss
  • Low magnesium
  • Low potassium
  • Decrease in white blood cells (higher risk of infection)
  • Anemia, (low red blood cells, which can be treated with a blood transfusion)
  • Low platelets (thrombocytopenia, can lead to intestinal bleeding)
  • Kidney toxicity, hematuria (abnormal presence of blood in the urine)
  • Low calcium
  • Hair loss (Alopecia). This condition is only temporary and hair grows back once treatment is complete

When To Call the doctor
(Emergency that needs professional support)

  • Fever of 38°C or higher or chills, can be a sign of serious infection due to a weak immune system
  • Vomiting (> 4 times in 24h)
  • Diarrhea (> 4 episodes in 24h)
  • No urine output in a 12 hour period
  • Black stool; could be a sign of intestinal bleedings
  • Disorientation and seizures
  • Injection site reactions (redness, pain, or swelling)

Ifosfamide is not allowed for use in patients with bone marrow suppression as this can result in more serious complications.